PKD2L1

polycystin 2 like 1, transient receptor potential cation channel

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000107593
UniProt:: Q9P0L9
OMIM:: 604532
Synonyms:: PCL, PKD2L, PKDL, TRPP3

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia

References: PMID:24336288, PMID:29230552

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Ciliary membrane

Function

PKD1L1-PKD2L1 acts as a ciliary calcium channel controlling ciliary calcium concentration and thereby modifying SMO-activated GLI2 translocation and GLI1 expression (24336288). Plays a role in localization with β2- adrenergic receptor (β2AR) on the neuronal primary cilia (29230552).

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