PKM

pyruvate kinase M1/2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000067225
UniProt:: P14618
OMIM:: 179050
Synonyms:: PKM2, PK3, OIP3, CTHBP, THBP1

Subcellular localization

cilia

References: PMID:42182460

Functional category

Metabolism

Function

Both PKM isoforms, PKm1 and PKm2, localize to primary cilia of human and mouse pancreatic islet beta cells; beta-cell knockouts confirmed the antibody staining. PKm1, but not PKm2, is required for glucose- and amino acid-stimulated ATP production in cilia (PMID 42182460).

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