PKN1

protein kinase N1

Ensembl:
ENSG00000123143
UniProt:
Q16512
OMIM:
601032
Synonyms:
DBK, MGC46204, PAK1, PKN, PRK1

Cilia effects upon perturbation of PKN1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=981, lfc=0.61) PMID:30270045

Subcellular localization

cilia, nucleus, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone
  • Transcription regulation

Function

pPRK1/pPRK2 localise to the transition zone of cilia and their co-depletion results in reduced cilia size, impaired planer polarity and impaired cilia associated sig lling(32127582).