PLA2G3

phospholipase A2 group III

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000100078
UniProt:
Q9NZ20
OMIM:
611651
Synonyms:
GIII-SPLA2

Cilia effects upon perturbation of PLA2G3

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

centrosome, transition zone

References: PMID:25904332

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion
  • Transition zone

Function

Negative ciliogenesis regulator. Depletion of PLA2G3 facilitates cilium extension and induces ciliogenesis independent of serum starvation (20393563). Mediator of SREBP1c-induced cilium repression by distorting vesicular trafficking (25904332).