PLCB2

phospholipase C beta 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000137841
UniProt:
Q00722
OMIM:
604114
Synonyms:
FLJ38135

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.18) PMID:20393562

Phenotypes

Mouse phenotype:
abnormal spleen morphology, decreased locomotor activity, abnormal vocalization, enlarged spleen, decreased pulmory ventilation

Subcellular localization

basal body, cytosol, endosome

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PLCB2 has localized in basal body.