PLCG1

phospholipase C gamma 1

Ensembl:
ENSG00000124181
UniProt:
P19174
OMIM:
172420
Synonyms:
NCKAP3, PLC-II, PLC1, PLC148, PLCGAMMA1

Cilia effects upon perturbation of PLCG1

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.59) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PLCG1 was localized to the primary cilia, and depletion of PLCG1 alleviated primary ciliogenesis, suggesting a feedforward role for PLCG1 in mediating primary ciliogenesis(39820281).