PLEKHA8

pleckstrin homology domain containing A8

Ensembl:
ENSG00000106086
UniProt:
Q96JA3
OMIM:
608639
Synonyms:
FAPP2, MGC3358

Cilia effects upon perturbation of PLEKHA8

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
enlarged epididymis, abnormal epididymis morphology
Mouse ciliopathy phenotype:
abnormal kidney morphology, polycystic kidney

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly

Function

FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin–Darby canine kidney (MDCK) cells ( 17116893).