PLK1

polo like kinase 1

Ensembl:
ENSG00000166851
UniProt:
P53350
OMIM:
602098
Synonyms:
PLK

Cilia effects upon perturbation of PLK1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Decreased

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.47) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=3.69) PMID:20393562

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, embryonic lethality prior to tooth bud stage, embryonic lethality prior to organogenesis

Subcellular localization

basal body, centrosome, cytosol, microtubules, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Protein processing & maturation
  • Transition zone
  • Transcription regulation

Function

Regulates of centrosome maturation. Induces the phosphorylation of the transition zone protein nephrocystin-1 and modulates trafficking required for ciliary mainte nce or disassembly (22701722). Interacts with and activates histone deacetylase 6 (HDAC6) to promote ciliary deacetylation and resorption. Plk1 is recruited to the pericentriolar region by PCM1 (23345402).

Model organism evidence

Danio rerio (1 reference)

PLK4 plays a crucial role in centriole duplication, which is essential for maintaining cellular processes such as cell division, cytoskeletal stability, and cilia formation.

PMIDs: 39304174