PLK4

polo like kinase 4

Ensembl:
ENSG00000142731
UniProt:
O00444
OMIM:
605031
Synonyms:
SAK, STK18

Cilia effects upon perturbation of PLK4

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia
Overexpression effect:
No dramatic change

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.95) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=3.66) PMID:20393562

Subcellular localization

basal body, centrosome, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Role in pericentrosomal localisation and integrity of centriolar satellite and ciliogenesis through PCM1 phosphorylation (26755742). Interacts with CEP78. Over-expression induces centrosome amplification, which prevents the formation of basal bodies leading to loss of primary cilia (26701933, 27246242).

Model organism evidence

Danio rerio (1 reference)

PLK4 plays a crucial role in centriole duplication, which is essential for maintaining cellular processes such as cell division, cytoskeletal stability, and cilia formation.

PMIDs: 39304174