PLPP3

phospholipid phosphatase 3

Ensembl:: ENSG00000162407
UniProt:: O14495
OMIM:: 607125
Synonyms:: LPP3, PAP-2B, PPAP2B

Cilia effects upon perturbation of PLPP3

Ciliogenesis screen results (1 screen)

Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, embryonic lethality prior to tooth bud stage, decreased mean corpuscular hemoglobin
Mouse ciliopathy phenotype:: increased circulating creatinine level

Subcellular localization

flagella

Functional category

Actin & cytoskeleton regulation
Cell migration & adhesion
Transcription regulation

Function

PLPP3 has localized in flagella.

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