PLSCR1

phospholipid scramblase 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000188313
UniProt:: O15162
OMIM:: 604170
Synonyms:: MMTRA1B

Ciliogenesis screen results (5 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.88) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.18) PMID:20393562

Subcellular localization

cytosol, nucleus

References: PMID:25139857

Functional category

Ciliary assembly/disassembly
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)

Function

si:ch211-71m22.1 (PLSCR1 in human) and slc43a3a are required for the function of all motile cilia, except for those in the otic vesicle, whereas two genes encoding putative guanine nucleotide exchange factors, arhgef18b and ect2l, are needed for the function of motile cilia in just the developing ear and KV ( 25139857).

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