PNPLA5
patatin like domain 5, triacylglycerol lipase
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000100341
- UniProt:
- Q7Z6Z6
- OMIM:
- 611589
- Synonyms:
- DJ388M5.4, GS2L
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=553, lfc=-0.50) PMID:30270045
Phenotypes
- Mouse phenotype:
- abnormal spleen morphology, enlarged spleen
Subcellular localization
flagella
References: PMID:25613900
Function
PNPLA5 has localized in flagella.