PNPLA5

patatin like domain 5, triacylglycerol lipase

Ensembl:
ENSG00000100341
UniProt:
Q7Z6Z6
OMIM:
611589
Synonyms:
DJ388M5.4, GS2L

Cilia effects upon perturbation of PNPLA5

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=553, lfc=-0.50) PMID:30270045

Phenotypes

Mouse phenotype:
abnormal spleen morphology, enlarged spleen

Subcellular localization

flagella

Function

PNPLA5 has localized in flagella.

Model organism evidence

Mus musculus (1 reference)

Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death.

PMIDs: 16113289