POC1B

POC1 centriolar protein B

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000139323
UniProt:
Q8TC44
OMIM:
614784
Synonyms:
FLJ14923, TUWD12, WDR51B

Cilia effects upon perturbation of POC1B

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

  • Cone-Rod Dystrophy

References: PMID:24945461, PMID:25044745, PMID:26188096

Subcellular localization

basal body, centrosome

References: PMID:26336158, PMID:23015594, PMID:25044745, PMID:25018096

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Stable component of centrioles that and plays a role in their formation and maintenance, required for ciliogenesis (26336158, 23015594, 25044745). Disease gene for recessive retinal degeneration and severe syndromic ciliopathy (25018096).