POGZ

pogo transposable element derived with ZNF domain

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000143442
UniProt:
Q7Z3K3
OMIM:
614787
Synonyms:
KIAA0461, ZNF280E, ZNF635

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.18) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.14) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome; Intellectual disability

Subcellular localization

basal body, nucleus, transition zone, motile cilia

References: PMID:41005307, PMID:39677731

Functional category

  • Ciliary assembly/disassembly
  • Transition zone

Function

POGZ has localized in basal body, transition zone. GFP-tagged POGZ, an autism-associated chromatin regulator, localizes to motile cilia (Kostyanovskaya et al., 2025, bioRxiv, PMID 39677731).