POLA2

DNA polymerase alpha 2, accessory subunit

Ensembl:
ENSG00000014138
UniProt:
Q14181
OMIM:
620063
Synonyms:
FLJ21662

Cilia effects upon perturbation of POLA2

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-14.56) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, embryonic lethality prior to tooth bud stage, embryonic lethality prior to organogenesis

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

POLA2 has localized in basal body.

Model organism evidence

Mus musculus (1 reference)

Enteritidis wild-type strains and isogenic aflagellate mutants were assessed on HEp-2 and Div-1 cells that are of human and avian epithelial origin, respectively.

PMIDs: 14503791