POLA2

DNA polymerase alpha 2, accessory subunit

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000014138
UniProt:
Q14181
OMIM:
620063
Synonyms:
FLJ21662

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-14.56) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, embryonic lethality prior to tooth bud stage, embryonic lethality prior to organogenesis

Subcellular localization

basal body, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly

Function

POLA2 has localized in basal body.