POMK

protein O-mannose kinase

Ensembl:: ENSG00000185900
UniProt:: Q9H5K3
OMIM:: 615247
Synonyms:: FLJ23356, SGK196

Cilia effects upon perturbation of POMK

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=897, lfc=-1.56) PMID:30270045

Phenotypes

Mouse phenotype:: decreased startle reflex, preweaning lethality, complete penetrance, increased bone mineral density, increased spleen weight
Mouse ciliopathy phenotype:: abnormal kidney morphology

Subcellular localization

cilia associated gene

Functional category

Ciliary assembly/disassembly
Reproduction & sperm

Function

Hydrocephalus and infertility due to dysfunctio l motile cilia, cerebellar dysplasia in KO mouse 21746835

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