POU5F1

POU class 5 homeobox 1

Ensembl:
ENSG00000235068, ENSG00000230336, ENSG00000229094, ENSG00000204531, ENSG00000206454, ENSG00000233911, ENSG00000237582
UniProt:
Q01860
OMIM:
164177
Synonyms:
MGC22487, OCT-4, OCT3, OCT3/4, OCT4

Cilia effects upon perturbation of POU5F1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.41) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

Oct4 colocalized with alpha-tubulin to the eye of a 8-week human embryo(26255818).