PPARA
peroxisome proliferator activated receptor alpha
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000186951
- UniProt:
- Q07869
- OMIM:
- 170998
- Synonyms:
- HPPAR, NR1C1, PPAR
Cilia effects upon perturbation of PPARA
- Cilia number / % ciliated:
- Incrased cilia number
- Overexpression effect:
- Increased
Ciliogenesis screen results (5 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.98) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.38) PMID:41160700
Phenotypes
- Mouse phenotype:
- abnormal skin coloration, abnormal coat appearance
Subcellular localization
basal body, cilia, nucleus
References: PMID:41005307, PMID:29771182
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Metabolism
- Viral interactions
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Transcription regulation
Function
Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo. Regulates autophagy by controlling transcription of genes involved in autophagic pathways, and activation of PPARA facilitated ciliogenesis independently of cellular nutritional states by activating autophagy (29771182).