PPARA

Cilia effects upon perturbation of PPARA

Cilia number / % ciliated:

Incrased cilia number

Overexpression effect:

Increased

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.98) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.38) PMID:41160700

Phenotypes

Mouse phenotype:

abnormal skin coloration, abnormal coat appearance

Subcellular localization

basal body, cilia, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Metabolism
• Viral interactions
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• Transcription regulation

Function

Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo. Regulates autophagy by controlling transcription of genes involved in autophagic pathways, and activation of PPARA facilitated ciliogenesis independently of cellular nutritio l states by activating autophagy (29771182).