PPL

periplakin

Ensembl:
ENSG00000118898
UniProt:
O60437
OMIM:
602871

Cilia effects upon perturbation of PPL

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-12.97) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
hypoplasia, abnormal skin morphology, liquefactive necrosis, dystrophy, decreased exploration in new environment, enlarged lymph nodes
Mouse ciliopathy phenotype:
small kidney

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

PPL has localized in basal body.