PPP1CA

protein phosphatase 1 catalytic subunit alpha

Ensembl:
ENSG00000172531
UniProt:
P62136
OMIM:
176875
Synonyms:
PP-1A, PP1A, PP1ALPHA, PPP1A

Cilia effects upon perturbation of PPP1CA

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.90) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.61) PMID:41160700

Subcellular localization

basal body, cytosol, flagella, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

PPP1CA has localized in basal body,flagella.