PPP1CB

protein phosphatase 1 catalytic subunit beta

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000213639
OMIM:: 600590
Synonyms:: MP, PP-1B, PP1B, PP1BETA, PP1C, PPP1BETA

Subcellular localization

Nucleoplasm, Cytosol

References: PMID:36693320

Functional category

Signaling (Hedgehog
GPCRs
ion channels)
Ciliary assembly/disassembly

Function

Cilia number in DKO cells was partially rescued by double siRNA knockdown of the PP1 catalytic subunits A and B (PPP1CA and PPP1CB), confirming a specific role for PP1 in WNT/GSK3-mediated ciliogenesis (Figure 6I, knockdown efficiency confirmed in Figure S6H)(36693320).

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