PPP1R2

protein phosphatase 1 regulatory inhibitor subunit 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000184203
UniProt:
P41236
OMIM:
601792
Synonyms:
IPP2, PPP1R2A

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.55) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:36693320

Functional category

  • Ciliary assembly/disassembly

Function

WNT/GSK3 signaling independent of β-catenin inhibits ciliary PP1 in cilia via PPP1R2 (36693320).