PPP1R42

protein phosphatase 1 regulatory subunit 42

Ensembl:
ENSG00000178125
UniProt:
Q7Z4L9
OMIM:
617720
Synonyms:
DTR, LRRC67, TLLR

Cilia effects upon perturbation of PPP1R42

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Unknown
Overexpression effect:
Unknown

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.18) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
vertebral fusion

Subcellular localization

basal body, centrosome

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Regulates PP1 activity at the centrosome. It activates PP1 to negatively regulate NEK2, suppressing centrosome separation (23718219). PPP1R42 overexpression induces an increase in cilia number and length (29141582).