PPP2R5E

protein phosphatase 2 regulatory subunit B'epsilon

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000154001
UniProt:: Q16537
OMIM:: 601647
Synonyms:: B56E, B56EPSILON

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=631, lfc=-1.78) PMID:30270045

Phenotypes

Mouse phenotype:: increased mean corpuscular volume, decreased locomotor activity, decreased mean platelet volume, increased hematocrit, decreased exploration in new environment, abnormal bone structure, abnormal locomotor behavior, decreased bone mineral content, decreased mean corpuscular hemoglobin concentration

Subcellular localization

flagella

References: PMID:41005307

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Signaling (Hedgehog, GPCRs, ion channels)

Function

PPP2R5E has localized in flagella.

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