PPP2R5E

protein phosphatase 2 regulatory subunit B'epsilon

Ensembl:
ENSG00000154001
UniProt:
Q16537
OMIM:
601647
Synonyms:
B56E, B56EPSILON

Cilia effects upon perturbation of PPP2R5E

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=631, lfc=-1.78) PMID:30270045

Phenotypes

Mouse phenotype:
increased mean corpuscular volume, decreased locomotor activity, decreased mean platelet volume, increased hematocrit, decreased exploration in new environment, abnormal bone structure, abnormal locomotor behavior, decreased bone mineral content, decreased mean corpuscular hemoglobin concentration
Mouse ciliopathy phenotype:
abnormal auditory brainstem response

Subcellular localization

flagella

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PPP2R5E has localized in flagella.