PPP3R2

protein phosphatase 3 regulatory subunit B, beta

Ensembl:
ENSG00000188386
UniProt:
Q96LZ3
OMIM:
613821
Synonyms:
PPP3RL

Cilia effects upon perturbation of PPP3R2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=835, lfc=-0.40) PMID:30270045

Phenotypes

Mouse phenotype:
increased red blood cell distribution width
Mouse ciliopathy phenotype:
male infertility

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Reproduction & sperm

Function

PPP3R2 has localized in ciliary tip, primary cilia.