PPP5C

Cilia effects upon perturbation of PPP5C

Cilia number / % ciliated:

Incrased cilia number

Loss-of-function effect:

Shorter cilia

Overexpression effect:

Increased

Ciliogenesis screen results (4 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.40) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=437, lfc=0.71) PMID:30270045

Phenotypes

Mouse phenotype:

abnormal rib morphology, neoplasm, vertebral fusion, increased lumbar vertebrae number, abnormal coat/hair pigmentation, decreased circulating glucose level, increased rib number, decreased circulating triglyceride level, decreased body length, increased lean body mass, increased thoracic vertebrae number

Subcellular localization

basal body, cytosol, nucleus

Functional category

• Ciliary assembly/disassembly
• Protein processing & maturation
• Signaling (Hedgehog, GPCRs, ion channels)

Function

PP5 interacts with and directly dephosphorylates Dvl2. Overexpression enhaces ciliogenesis (29426949).