PPT1

palmitoyl-protein thioesterase 1

Ensembl:
ENSG00000131238
UniProt:
P50897
OMIM:
600722
Synonyms:
CLN1, INCL, PPT

Cilia effects upon perturbation of PPT1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, lysosomes, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PPT1 is an important depalmitoylation enzyme, is regulated through reversible S-acylation(26731412).

Model organism evidence

Mus musculus (1 reference)

Here, we provide proteomic evidence suggesting that PPT1 deficiency could be considered as a ciliopathy.

PMIDs: 28334871