PRC1

protein regulator of cytokinesis 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000198901
OMIM:: 603484
Synonyms:: ASE1, MAP65

Phenotypes

Mouse phenotype:: cataract, abnormal lens morphology, abnormal retina morphology, persistence of hyaloid vascular system

Subcellular localization

basal body, Nucleoplasm, Plasma membrane, Microtubules, Cytokinetic bridge, Midbody

References: PMID:21246755

Functional category

Metabolism
Cilia–cytoskeleton/adhesion links

Function

We show that several central spindle/midbody proteins (PRC1, MKLP-1, INCENP, centriolin) also localize in specific patterns at the basal body complex in vertebrate ciliated epithelial cells. Moreover, bioinformatic comparisons of midbody and cilia proteomes reveal a highly significant degree of overlap. Finally, we used temperature-sensitive alleles of PRC1/spd-1 and MKLP-1/zen-4 in C. elegans to assess ciliary functions while bypassing these proteins' early role in cell division(21246755).

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