PRDX1

peroxiredoxin 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000117450
UniProt:: Q06830
OMIM:: 176763
Synonyms:: NKEFA, PAGA

Cilia effects upon perturbation of PRDX1

Cilia number / % ciliated:: Incrased cilia number
Loss-of-function effect:: Longer cilia
Overexpression effect:: Decreased

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cytosol, nucleus, peroxisome

References: PMID:24480440, PMID:32357862

Functional category

Ciliary assembly/disassembly

Function

Antioxidant protein, involved in in the regulation of cilium disassembly ( 24480440) and decreases the activity of Aurora A, through the regulation of the critical NEDD9-Aurora A-HDAC6 signal axis ( 32357862).

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