PRDX1
peroxiredoxin 1
- Ensembl:
- ENSG00000117450
- UniProt:
- Q06830
- OMIM:
- 176763
- Synonyms:
- NKEFA, PAGA
Cilia effects upon perturbation of PRDX1
- Cilia number / % ciliated:
- Incrased cilia number
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- Decreased
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia associated gene, cytosol, nucleus, peroxisome
Functional category
- Ciliary assembly/disassembly
Function
Antioxidant protein, involved in in the regulation of cilium disassembly ( 24480440) and decreases the activity of Aurora A, through the regulation of the critical NEDD9-Aurora A-HDAC6 sig l axis ( 32357862).
Model organism evidence
Mus musculus (6 references)
Intraflagellar transport (IFT) proteins have been reported to regulate cell growth and differentiation as the essential functional component of primary cilia.
Primary cilia were absent on chondrocytes of Ift20:Prx1-Cre mice, and ciliary-mediated Hedgehog signaling was attenuated in Ift20:Prx1-Cre mice.