PRICKLE1

prickle planar cell polarity protein 1

Ensembl:: ENSG00000139174
UniProt:: Q96MT3
Synonyms:: EPM1B, FLJ31937, RILP

Cilia effects upon perturbation of PRICKLE1

Ciliogenesis screen results (5 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.13) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.66, ciliated=58.0%) PMID:26595381
Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.94) PMID:20393562

Subcellular localization

basal body, cytosol, nucleus

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Cell migration & adhesion
Signaling (Hedgehog, GPCRs, ion channels)
Cardiac & muscle development
Transcription regulation

Function

Also known as PK1. Regulates cell polarity and directio l cell migration. It may also be involved in ciliogenesis. Pk1 mutants exhibited primary and motile cilia defects (26883626).

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