PRICKLE2

prickle planar cell polarity protein 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000163637
UniProt:: Q7Z3G6
OMIM:: 608501
Synonyms:: DKFZP686D143

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.64) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

References: PMID:24708399, PMID:24938409

Functional category

Ciliary assembly/disassembly

Function

Also known as PK2. Planar cell polarity core component involved in the development and function of motile cilia (24708399). Role in anterograde transport. Required for basal body and cilia orientation (24938409).

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