PRICKLE3

prickle planar cell polarity protein 3

Ensembl:
ENSG00000012211
UniProt:
O43900
OMIM:
300111
Synonyms:
LMO6

Cilia effects upon perturbation of PRICKLE3

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

Also known as PK3. Required for gamma-tubulin and Nedd1 recruitment to the basal body, necessary for basal body organization and cilia growth. Pk3 knockdown inhibites ciliogenesis (27062996).

Model organism evidence

Mus musculus (1 reference)

Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth.

PMIDs: 27062996

Drosophila (2 references)

Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth.

The planar cell polarity (PCP) pathway orients cells in diverse epithelial tissues in Drosophila and vertebrate embryos and has been implicated in many human congenital defects and diseases, such as ciliopathies, polycystic kidney disease and malignant cancers.

PMIDs: 27062996, 26079437

Xenopus (2 references)

Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth.

The planar cell polarity (PCP) pathway orients cells in diverse epithelial tissues in Drosophila and vertebrate embryos and has been implicated in many human congenital defects and diseases, such as ciliopathies, polycystic kidney disease and malignant cancers.

PMIDs: 27062996, 26079437