PRICKLE3

prickle planar cell polarity protein 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000012211
UniProt:: O43900
OMIM:: 300111
Synonyms:: LMO6

Cilia effects upon perturbation of PRICKLE3

Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

References: PMID:27062996

Functional category

Ciliary assembly/disassembly

Function

Also known as PK3. Required for gamma-tubulin and Nedd1 recruitment to the basal body, necessary for basal body organization and cilia growth. Pk3 knockdown inhibites ciliogenesis (27062996).

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