PRKAA2

protein kinase AMP-activated catalytic subunit alpha 2

Ensembl:
ENSG00000162409
UniProt:
P54646
OMIM:
600497
Synonyms:
AMPK, AMPKA2, PRKAA

Cilia effects upon perturbation of PRKAA2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.52) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.80) PMID:20393562

Phenotypes

Mouse phenotype:
enlarged spleen, increased circulating creatine kise level, decreased fasting circulating glucose level, decreased circulating alkaline phosphatase level, decreased circulating serum albumin level, decreased exploration in new environment, decreased mean platelet volume, decreased circulating fructosamine level
Mouse ciliopathy phenotype:
increased circulating aspartate transamise level, increased circulating alanine transamise level

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PRKAA2 has localized in basal body.