PRKACA

protein kinase cAMP-activated catalytic subunit alpha

Ensembl:
ENSG00000288516, ENSG00000072062
UniProt:
P17612
OMIM:
601639
Synonyms:
PKACA

Cilia effects upon perturbation of PRKACA

Overexpression effect:
Increased

Ciliogenesis screen results (5 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.41) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=517, lfc=-1.07) PMID:30270045
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.35) PMID:41160700

Ciliopathy associations

  • Ellis-van Creveld Syndrome-like phenotype
  • Skeletal Ciliopathy

Subcellular localization

basal body, centrosome, cilia, cytosol, mitochondria, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Reproduction & sperm
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology
  • Transcription regulation

Function

Catalytic subunit of PKA. At centriolar satellites. Part of a multimeric complex nucleated by PCM1. Phosphorylates NEK10 for CHIP-mediated ubiquiti tion and proteolysis resulting in cilia resorption. Patched1-ArhGAP36-PKA- Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation. 30598432

Model organism evidence

Mus musculus (1 reference)

Capacitation of mammalian sperm, including alterations in flagellar motility, is presumably modulated by chemical signals encountered in the female reproductive tract.

PMIDs: 16291925