PRKACB

protein kinase cAMP-activated catalytic subunit beta

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000142875
UniProt:
P22694
OMIM:
176892
Synonyms:
PKACB

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance

Ciliopathy associations

  • Cardioacrofacial Dysplasia 2
  • Ellis-van Creveld Syndrome

References: PMID:35927022, PMID:33058759

Subcellular localization

basal body, centrosome, cilia, cytosol, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PRKACB has localized in basal body.