PRKACB

protein kinase cAMP-activated catalytic subunit beta

Ensembl:
ENSG00000142875
UniProt:
P22694
OMIM:
176892
Synonyms:
PKACB

Cilia effects upon perturbation of PRKACB

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance
Mouse ciliopathy phenotype:
increased circulating alanine transamise level

Ciliopathy associations

  • Ellis-van Creveld Syndrome-like phenotype

Subcellular localization

basal body, centrosome, cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PRKACB has localized in basal body.

Model organism evidence

Mus musculus (1 reference)

Capacitation of mammalian sperm, including alterations in flagellar motility, is presumably modulated by chemical signals encountered in the female reproductive tract.

PMIDs: 16291925