PRKACG

protein kinase cAMP-activated catalytic subunit gamma

Ensembl:
ENSG00000165059
UniProt:
P22612
OMIM:
176893
Synonyms:
PKACG

Cilia effects upon perturbation of PRKACG

Ciliogenesis screen results (2 screens)

  • Kim2016: Not Reported
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Catalytic subunit of PKA. At centriolar satellites. Part of a multimeric complex nucleated by PCM1. Phosphorylates NEK10 for CHIP-mediated ubiquiti tion and proteolysis resulting in cilia resorption. Patched1-ArhGAP36-PKA- Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation. 30598432

Model organism evidence

Mus musculus (1 reference)

Capacitation of mammalian sperm, including alterations in flagellar motility, is presumably modulated by chemical signals encountered in the female reproductive tract.

PMIDs: 16291925