PRKACG

protein kinase cAMP-activated catalytic subunit gamma

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000165059
UniProt:: P22612
OMIM:: 176893
Synonyms:: PKACG

Ciliogenesis screen results (2 screens)

Kim2016: Not Reported
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, cytosol

References: PMID:41005307, PMID:30598432

Functional category

Ciliary assembly/disassembly
Metabolism
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)

Function

Catalytic subunit of PKA. At centriolar satellites. Part of a multimeric complex nucleated by PCM1. Phosphorylates NEK10 for CHIP-mediated ubiquitination and proteolysis resulting in cilia resorption. Patched1-ArhGAP36-PKA- Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation. 30598432

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