PRKAR1A

protein kinase cAMP-dependent type I regulatory subunit alpha

Ensembl:: ENSG00000108946
UniProt:: P10644
OMIM:: 188830
Synonyms:: CNC1, PKR1, PRKAR1, PRKAR1ALPHA, TSE1

Cilia effects upon perturbation of PRKAR1A

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.9) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol

Functional category

Signaling (Hedgehog, GPCRs, ion channels)

Function

PRKAR1A encodes the PKA regulatory subunit RIα, which localizes to primary cilia and regulates cilia-dependent Hedgehog and cAMP signaling (PMID: 26585297, PMID: 21266715). Kidney-specific loss of Prkar1a induces cystic kidney disease and markedly aggravates Pkd1-associated cystogenesis, establishing PRKAR1A as a ciliary signaling regulator relevant to ciliopathies(PMID: 28615245).

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