PRKAR2A

protein kinase cAMP-dependent type II regulatory subunit alpha

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000114302
UniProt:
P13861
OMIM:
176910
Synonyms:
PRKAR2

Cilia effects upon perturbation of PRKAR2A

Loss-of-function effect:
No effect
Overexpression effect:
No effect

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

centrosome, cilia, cytosol, basal body

References: PMID:41005307, PMID:18687752

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

P2Y12 purinergic receptor, adenylyl cyclases (i.e., AC4, AC6, and AC8), and protein kinase A (i.e., PKA RI-β and PKA RII-α regulatory subunits), exchange protein directly activated by cAMP (EPAC) isoform 2, and A-kinase anchoring proteins (i.e., AKAP150) are expressed in cholangiocyte cilia.