PRKAR2B

protein kinase cAMP-dependent type II regulatory subunit beta

Ensembl:
ENSG00000005249
UniProt:
P31323
OMIM:
176912
Synonyms:
PRKAR2

Cilia effects upon perturbation of PRKAR2B

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.54) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.18) PMID:41160700

Subcellular localization

basal body, centrosome, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PKARII尾 was colocalized with AKAP9 to centrosome-Golgi in all the wild type cells examined (PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog sig ling in cilia and reduced in Talpid3 mutant).