PRKCG
protein kinase C gamma
- Ensembl:
- ENSG00000126583
- UniProt:
- P05129
- OMIM:
- 176980
- Synonyms:
- MGC57564, PKCC, PKCG, SCA14
Cilia effects upon perturbation of PRKCG
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Human ciliopathy phenotype:
- spinocerebellar ataxia type 14
Subcellular localization
cilia associated gene, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Mutations in the PRKCG gene cause Spinocerebellar Ataxia (PMID: 14676051, 12644968).