PRKCI

protein kinase C iota

Ensembl:
ENSG00000163558
UniProt:
P41743
OMIM:
600539
Synonyms:
DXS1179E, PKCI

Cilia effects upon perturbation of PRKCI

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.39) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=554, lfc=-2.29) PMID:30270045

Subcellular localization

cilia, cytosol, flagella, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Crumbs-associated Par3/Par6/aPKC polarity cassette localizes to cilia and regulates ciliogenesis (15324661).