PRKCZ

Cilia effects upon perturbation of PRKCZ

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

developmental and structural abnormality, decreased circulating creatinine level, increased circulating ldl cholesterol level, increased circulating alkaline phosphatase level, increased lactate dehydrogese level, increased circulating iron level

Mouse ciliopathy phenotype:

increased circulating alanine transamise level, increased circulating aspartate transamise level

Subcellular localization

basal body, cytosol, microtubules, nucleus

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• T cell biology
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Transcription regulation

Function

PRKCZ has localized in basal body.