PRKCZ

protein kinase C zeta

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000067606
UniProt:
Q05513
OMIM:
176982
Synonyms:
PKC2

Cilia effects upon perturbation of PRKCZ

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
developmental and structural abnormality, decreased circulating creatinine level, increased circulating ldl cholesterol level, increased circulating alkaline phosphatase level, increased lactate dehydrogese level, increased circulating iron level

Subcellular localization

basal body, cytosol, microtubules, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

PRKCZ has localized in basal body.