PRKD1

protein kinase D1

Ensembl:
ENSG00000184304
UniProt:
Q15139
OMIM:
605435
Synonyms:
PKC-MU, PKCM, PKD, PRKCM

Cilia effects upon perturbation of PRKD1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.69) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, casTLE effect=0.41) PMID:29459680

Phenotypes

Mouse phenotype:
increased leukocyte cell number, increased mean corpuscular hemoglobin, increased circulating insulin level, increased mean corpuscular hemoglobin concentration
Human ciliopathy phenotype:
congenital heart defects and ectodermal dysplasia

Subcellular localization

cilia associated gene, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology
  • Transcription regulation

Function

Golga2 and prkd1 are expressed at later stage in the developing pronephric tubule where golgin A2 and protein ki se‐D1 might also interact with TRPP2 ( 30171710).