PRKD3

protein kinase D3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000115825
UniProt:: O94806
OMIM:: 607077
Synonyms:: EPK2, PRKCN

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased circulating cholesterol level, decreased total reti thickness, impaired glucose tolerance, preweaning lethality, incomplete penetrance, decreased circulating hdl cholesterol level

Subcellular localization

cilia, nucleus, basal body

References: PMID:41005307

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

PRKD3 has localized in cilia.

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