PRKD3

protein kinase D3

Ensembl:: ENSG00000115825
UniProt:: O94806
OMIM:: 607077
Synonyms:: EPK2, PRKCN

Cilia effects upon perturbation of PRKD3

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased circulating cholesterol level, decreased total reti thickness, impaired glucose tolerance, preweaning lethality, incomplete penetrance, decreased circulating hdl cholesterol level
Mouse ciliopathy phenotype:: abnormal reti blood vessel morphology, increased circulating aspartate transamise level

Subcellular localization

cilia, nucleus

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

PRKD3 has localized in cilia.

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.