PRKG2

protein kinase cGMP-dependent 2

Ensembl:
ENSG00000138669
UniProt:
Q13237
OMIM:
601591
Synonyms:
CGKII, PKG2, PRKGR2

Cilia effects upon perturbation of PRKG2

Ciliogenesis screen results (6 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.62) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=878, lfc=-1.54) PMID:30270045
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.38) PMID:41160700

Subcellular localization

cilia associated gene, cytosol

Functional category

  • Ciliary assembly/disassembly
  • ECM & connective tissue

Function

Mutations in the PRKG2 gene cause Spondylometaphyseal Dysplasia (PMID: 34782440).

Model organism evidence

C. elegans (1 reference)

Ciliopathies are pleiotropic and genetically heterogeneous disorders caused by defective development and function of the primary cilium.

PMIDs: 22022287