PRKG2

protein kinase cGMP-dependent 2

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000138669
UniProt:
Q13237
OMIM:
601591
Synonyms:
CGKII, PKG2, PRKGR2

Ciliogenesis screen results (6 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.62) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=878, lfc=-1.54) PMID:30270045
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.38) PMID:41160700

Subcellular localization

cytosol

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • ECM & connective tissue

Function

Mutations in the PRKG2 gene cause Spondylometaphyseal Dysplasia (PMID: 34782440).