PRLHR

prolactin releasing hormone receptor

Ensembl:
ENSG00000119973
UniProt:
P49683
OMIM:
600895
Synonyms:
GPR10, PRRPR

Cilia effects upon perturbation of PRLHR

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.60) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

PRLHR, also known as GPR10, was identified as a receptor for PRLH [9607765]. Prlhr-knockout mice and Prlhr-null rats (OLETF rats) exhibited obesity and hyperphagia [14742914], and PRLHR localizes to cilia (26053317).

Model organism evidence

C. elegans (1 reference)

Regulation of hyperoxia-induced social behaviour in Pristionchus pacificus nematodes requires a novel cilia-mediated environmental input.

PMIDs: 29242625

Mus musculus (1 reference)

We found that several GPCRs whose ligands are involved in feeding behavior, including prolactin-releasing hormone receptor (PRLHR), neuropeptide FF receptor 1 (NPFFR1), and neuromedin U receptor 1 (NMUR1), localized to the primary cilia.

PMIDs: 26053317