PROK2

Cilia effects upon perturbation of PROK2

Ciliogenesis screen results (6 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=3.14) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=238, lfc=0.65) PMID:30270045
• Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.49) PMID:20393562

Phenotypes

Human ciliopathy phenotype:

hypogonadotropic hypogonadism; hypogonadotropic hypogonadism 4 with or without anosmia

Ciliopathy associations

• Kallmann Syndrome

Subcellular localization

cilia associated gene

Functional category

• Non-motile cilium / primary cilium

Function

Prok2 might affect the cellular composition and development of olfactory cilia in the OE and the formation of GL in the OB, according to the interval between E18.5 and 16 weeks (PMID: 40766783). PROK2 and its receptor PROKR2 contribute to primary cilium–dependent neuronal migration pathways. Mutations cause Kallmann syndrome, a recognized ciliopathy with variable penetrance and oligogenic inheritance (PMID: 20389090).