PROKR1

prokineticin receptor 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000169618
UniProt:: Q8TCW9
OMIM:: 607122
Synonyms:: PKR1, GPR73, GPR73a, ZAQ, EG-VEGF receptor 1

Subcellular localization

cilia

References: PMID:27736039

Functional category

Signaling (Hedgehog, GPCRs, ion channels)

Function

PROKR1 (prokineticin receptor 1) is a receptor for EG-VEGF (prokineticin 1). PROKR1 localizes to primary cilia of trophoblast cells, and cilium-dependent EG-VEGF signaling promotes trophoblast invasion (Wang et al., 2017, J Cell Physiol, PMID 27736039).

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