PROM2

prominin 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000155066
UniProt:
Q8N271
OMIM:
617160

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased circulating iron level, hyperactivity, increased mean corpuscular hemoglobin concentration, decreased grip strength, increased circulating potassium level, abnormal sleep behavior, abnormal il morphology, increased hemoglobin content

Subcellular localization

cilia, lysosomes

References: PMID:17109118

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Ciliary membrane

Function

prominin-2-GFP, like prominin-1 , was also found in cilia (revealed with anti-acetylated tubulin antibody) essentially at the bulging tip (17109118).