PROM2

Cilia effects upon perturbation of PROM2

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased circulating iron level, hyperactivity, increased mean corpuscular hemoglobin concentration, decreased grip strength, increased circulating potassium level, abnormal sleep behavior, abnormal il morphology, increased hemoglobin content

Mouse ciliopathy phenotype:

abnormal reti morphology, increased circulating alanine transamise level, increased circulating aspartate transamise level, decreased circulating calcium level

Subcellular localization

cilia, lysosomes

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Ciliary membrane

Function

prominin-2-GFP, like prominin-1 , was also found in cilia (revealed with anti-acetylated tubulin antibody) essentially at the bulging tip (17109118).