PSD3
pleckstrin and Sec7 domain containing 3
- Ensembl:
- ENSG00000156011
- UniProt:
- Q9NYI0
- OMIM:
- 614440
- Synonyms:
- DKFZP761K1423, EFA6D, EFA6R, HCA67, KIAA0942
Cilia effects upon perturbation of PSD3
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.47) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- decreased locomotor activity, increased bone mineral density, increased cardiac output, increased cardiac stroke volume, increased bone mineral content, decreased circulating total protein level, increased freezing behavior, impaired cued conditioning behavior, tremors
- Mouse ciliopathy phenotype:
- prolonged qrs complex duration
Subcellular localization
flagella
Functional category
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Function
PSD3 has localized in flagella.