PSD3

pleckstrin and Sec7 domain containing 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000156011
UniProt:: Q9NYI0
OMIM:: 614440
Synonyms:: DKFZP761K1423, EFA6D, EFA6R, HCA67, KIAA0942

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.47) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased locomotor activity, increased bone mineral density, increased cardiac output, increased cardiac stroke volume, increased bone mineral content, decreased circulating total protein level, increased freezing behavior, impaired cued conditioning behavior, tremors

Subcellular localization

flagella

References: PMID:41005307

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

PSD3 has localized in flagella.

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